1M52

Crystal Structure of the c-Abl Kinase domain in complex with PD173955

Summary for 1M52

• Entry DOI: 10.2210/pdb1m52/pdb
• Related: 1IEP
• Descriptor: PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1, 6-(2,6-DICHLORO-PHENYL)-8-METHYL-2-(3-METHYLSULFANYL-PHENYLAMINO)-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
• Functional Keywords: kinase, kinase inhibitor, pd173955, activation loop, transferase
• Biological source: Mus musculus (house mouse)
• Cellular location: Cytoplasm, cytoskeleton: P00520
• Total number of polymer chains: 2
• Total formula weight: 68764.22

Authors

Nagar, B.,Bornmann, W.,Pellicena, P.,Schindler, T.,Veach, D.,Miller, W.T.,Clarkson, B.,Kuriyan, J. (deposition date: 2002-07-08, release date: 2002-09-18, Last modification date: 2024-02-14)

• Primary citation: Nagar, B.,Bornmann, W.,Pellicena, P.,Schindler, T.,Veach, D.,Miller, W.T.,Clarkson, B.,Kuriyan, J.; Crystal Structures of the Kinase Domain of c-Abl in Complex with the Small Molecule Inhibitors PD173955 and Imatinib (STI-571); Cancer Res., 62:4236-4243, 2002; PubMed: 12154025

Experimental method

X-RAY DIFFRACTION (2.6 Å)