1M0B

HIV-1 protease in complex with an ethyleneamine inhibitor

Summary for 1M0B

Entry DOI	10.2210/pdb1m0b/pdb
Related	1FQX 1IIQ 1LZQ
Related PRD ID	PRD_000383
Descriptor	PROTEASE RETROPEPSIN, N-{(3S)-3-[(tert-butoxycarbonyl)amino]-4-phenylbutyl}-L-phenylalanyl-L-alpha-glutamyl-L-phenylalaninamide, GLYCEROL, ... (4 entities in total)
Functional Keywords	hiv protease, peptidomimetics, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
Total number of polymer chains	2
Total formula weight	22387.43
Authors	Petrokova, H.,Hasek, J.,Dohnalek, J. (deposition date: 2002-06-12, release date: 2004-01-13, Last modification date: 2024-02-14)
Primary citation	Petrokova, H.,Duskova, J.,Dohnalek, J.,Skalova, T.,Vondrackova-Buchtelova, E.,Soucek, M.,Konvalinka, J.,Brynda, J.,Fabry, M.,Sedlacek, J.,Hasek, J. Role of hydroxyl group and R/S configuration of isostere in binding properties of HIV-1 protease inhibitors Eur.J.Biochem., 271:4451-4461, 2004 Cited by PubMed: 15560786 DOI: 10.1111/j.1432-1033.2004.04384.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation