1LUV

CATALYTIC AND STRUCTURAL EFFECTS OF AMINO-ACID SUBSTITUTION AT HIS 30 IN HUMAN MANGANESE SUPEROXIDE DISMUTASE: INSERTION OF VAL CGAMMA INTO THE SUBSTRATE ACCESS CHANNEL

1LUV の概要

• エントリーDOI: 10.2210/pdb1luv/pdb
• 関連するPDBエントリー: 1ABM 1LUS 1LUW
• 分子名称: Superoxide dismutase [Mn], MANGANESE (II) ION (3 entities in total)
• 機能のキーワード: human manganese superoxide dismutase, wild type, high resolution, mnsod, mn, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion matrix: P04179
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44576.10

構造登録者

Hearn, A.S.,Stroupe, M.E.,Ramilo, C.A.,Luba, J.P.,Cabelli, D.E.,Tainer, J.A.,Silverman, D.N. (登録日: 2002-05-23, 公開日: 2002-06-19, 最終更新日: 2024-04-03)

• 主引用文献: Hearn, A.S.,Stroupe, M.E.,Cabelli, D.E.,Ramilo, C.A.,Luba, J.P.,Tainer, J.A.,Nick, H.S.,Silverman, D.N.; Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: insertion of valine C gamma into the substrate access channel; Biochemistry, 42:2781-2789, 2003; PubMed: 12627943; DOI: 10.1021/bi0266481

実験手法

X-RAY DIFFRACTION (1.85 Å)