1LI4

Human S-adenosylhomocysteine hydrolase complexed with neplanocin

Summary for 1LI4

Entry DOI	10.2210/pdb1li4/pdb
Descriptor	S-adenosylhomocysteine hydrolase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 3-(6-AMINO-PURIN-9-YL)-5-HYDROXYMETHYL-CYCLOPENTANE-1,2-DIOL, ... (5 entities in total)
Functional Keywords	alpha-beta structure, inhibitor complex, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P23526
Total number of polymer chains	1
Total formula weight	48821.84
Authors	Yang, X.,Hu, Y.,Yin, D.H.,Turner, M.A.,Wang, M.,Borchardt, R.T.,Howell, P.L.,Kuczera, K.,Schowen, R.L. (deposition date: 2002-04-17, release date: 2003-05-20, Last modification date: 2023-08-16)
Primary citation	Yang, X.,Hu, Y.,Yin, D.H.,Turner, M.A.,Wang, M.,Borchardt, R.T.,Howell, P.L.,Kuczera, K.,Schowen, R.L. Catalytic strategy of S-adenosyl-L-homocysteine hydrolase: Transition-state stabilization and the avoidance of abortive reactions Biochemistry, 42:1900-1909, 2003 Cited by PubMed: 12590576 DOI: 10.1021/bi0262350 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.01 Å)

Structure validation