1KW0

Catalytic Domain of Human Phenylalanine Hydroxylase (Fe(II)) in Complex with Tetrahydrobiopterin and Thienylalanine

1KW0 の概要

• エントリーDOI: 10.2210/pdb1kw0/pdb
• 関連するPDBエントリー: 1DMW 1J8T 1J8U 1PAH 2PAH
• 分子名称: Phenylalanine-4-hydroxylase, FE (II) ION, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (5 entities in total)
• 機能のキーワード: basket-arrangement 13 alpha-helices and 6 beta-strands, ferrous iron, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38069.88

構造登録者

Andersen, O.A.,Flatmark, T.,Hough, E. (登録日: 2002-01-28, 公開日: 2003-01-28, 最終更新日: 2023-08-16)

• 主引用文献: Andersen, O.A.,Flatmark, T.,Hough, E.; Crystal Structure of the Ternary Complex of the Catalytic Domain of Human Phenylalanine Hydroxylase with Tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its Implications for the Mechanism of Catalysis and Substrate Activation; J.Mol.Biol., 320:1095-1108, 2002; PubMed: 12126628; DOI: 10.1016/S0022-2836(02)00560-0

実験手法

X-RAY DIFFRACTION (2.5 Å)