1KV1

p38 MAP Kinase in Complex with Inhibitor 1

Summary for 1KV1

Entry DOI	10.2210/pdb1kv1/pdb
Related	1IAN 1KV2
Descriptor	p38 MAP kinase, 1-(5-TERT-BUTYL-2-METHYL-2H-PYRAZOL-3-YL)-3-(4-CHLORO-PHENYL)-UREA (3 entities in total)
Functional Keywords	protein-inhibitor complex, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm (By similarity): Q16539
Total number of polymer chains	1
Total formula weight	41649.99
Authors	Pargellis, C.,Tong, L.,Churchill, L.,Cirillo, P.F.,Gilmore, T.,Graham, A.G.,Grob, P.M.,Hickey, E.R.,Moss, N.,Pav, S.,Regan, J. (deposition date: 2002-01-23, release date: 2002-03-27, Last modification date: 2024-02-14)
Primary citation	Pargellis, C.,Tong, L.,Churchill, L.,Cirillo, P.F.,Gilmore, T.,Graham, A.G.,Grob, P.M.,Hickey, E.R.,Moss, N.,Pav, S.,Regan, J. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nat.Struct.Biol., 9:268-272, 2002 Cited by PubMed: 11896401 DOI: 10.1038/nsb770 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation