1KR3

Crystal Structure of the Metallo beta-Lactamase from Bacteroides fragilis (CfiA) in Complex with the Tricyclic Inhibitor SB-236050.

Summary for 1KR3

• Entry DOI: 10.2210/pdb1kr3/pdb
• Related: 1DD6 1ZNB
• Descriptor: beta-Lactamase, type II, ZINC ION, SODIUM ION, ... (5 entities in total)
• Functional Keywords: beta sandwich, protein-inhibitor complex, metallo, beta-lactamase, hydrolase
• Biological source: Bacteroides fragilis
• Cellular location: Periplasm : P25910
• Total number of polymer chains: 2
• Total formula weight: 51669.40

Authors

Payne, D.J.,Hueso-Rodrguez, J.A.,Boyd, H.,Concha, N.O.,Janson, C.A.,Gilpin, M.,Bateson, J.H.,Cheever, C.,Niconovich, N.L.,Pearson, S.,Rittenhouse, S.,Tew, D.,Dez, E.,Prez, P.,de la Fuente, J.,Rees, M.,Rivera-Sagredo, A. (deposition date: 2002-01-08, release date: 2003-01-08, Last modification date: 2023-08-16)

• Primary citation: Payne, D.J.,Hueso-Rodrguez, J.A.,Boyd, H.,Concha, N.O.,Janson, C.A.,Gilpin, M.,Bateson, J.H.,Cheever, C.,Niconovich, N.L.,Pearson, S.,Rittenhouse, S.,Tew, D.,Dez, E.,Prez, P.,de la Fuente, J.,Rees, M.,Rivera-Sagredo, A.; Identification of a series of tricyclic natural products as potent broad-spectrum inhibitors of metallo-beta-lactamases; ANTIMICROB.AGENTS CHEMOTHER., 46:1880-1886, 2002; PubMed: 12019104; DOI: 10.1128/AAC.46.6.1880-1886.2002

Experimental method

X-RAY DIFFRACTION (2.5 Å)