1KMV

HUMAN DIHYDROFOLATE REDUCTASE COMPLEXED WITH NADPH AND (Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE (SRI-9662), A LIPOPHILIC ANTIFOLATE

1KMV の概要

• エントリーDOI: 10.2210/pdb1kmv/pdb
• 関連するPDBエントリー: 1KMS
• 分子名称: DIHYDROFOLATE REDUCTASE, SULFATE ION, (Z)-6-(2-[2,5-DIMETHOXYPHENYL]ETHEN-1-YL)-2,4-DIAMINO-5-METHYLPYRIDO[2,3-D]PYRIMIDINE, ... (6 entities in total)
• 機能のキーワード: oxidoreductase, antiparasitic drugs, reductase, lipophilic antifolates
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22606.52

構造登録者

Klon, A.E.,Heroux, A.,Ross, L.J.,Pathak, V.,Johnson, C.A.,Piper, J.R.,Borhani, D.W. (登録日: 2001-12-17, 公開日: 2002-07-10, 最終更新日: 2024-04-03)

• 主引用文献: Klon, A.E.,Heroux, A.,Ross, L.J.,Pathak, V.,Johnson, C.A.,Piper, J.R.,Borhani, D.W.; Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution.; J.Mol.Biol., 320:677-693, 2002; PubMed: 12096917; DOI: 10.1016/S0022-2836(02)00469-2

実験手法

X-RAY DIFFRACTION (1.05 Å)