1KIM

CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH DEOXYTHYMIDINE

Replaces:  1KIN

Summary for 1KIM

• Entry DOI: 10.2210/pdb1kim/pdb
• Descriptor: THYMIDINE KINASE, SULFATE ION, THYMIDINE, ... (4 entities in total)
• Functional Keywords: transferase, phosphotransferase, thymidine kinase, viridae, ds-dna enveloped viruses, herpesviridae, alphaherpesvirinae
• Biological source: Herpes simplex virus (type 1 / strain 17)
• Total number of polymer chains: 2
• Total formula weight: 80401.72

Authors

Champness, J.N.,Bennett, M.S.,Wien, F.,Brown, D.G.,Visse, R.,Sandhu, G.,Davies, A.,Rizkallah, P.J.,Melitz, C.,Summers, W.C.,Sanderson, M.R. (deposition date: 1997-11-12, release date: 1998-05-20, Last modification date: 2024-02-14)

• Primary citation: Champness, J.N.,Bennett, M.S.,Wien, F.,Visse, R.,Summers, W.C.,Herdewijn, P.,de Clerq, E.,Ostrowski, T.,Jarvest, R.L.,Sanderson, M.R.; Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.; Proteins, 32:350-361, 1998; PubMed: 9715911; DOI: 10.1002/(SICI)1097-0134(19980815)32:3<350::AID-PROT10>3.0.CO;2-8

Experimental method

X-RAY DIFFRACTION (2.14 Å)