1KF9

PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR

1KF9 の概要

• エントリーDOI: 10.2210/pdb1kf9/pdb
• 分子名称: PHAGE DISPLAY DERIVED VARIANT HUMAN GROWTH HORMONE, EXTRACELLULAR DOMAIN HUMAN GROWTH HORMONE RECEPTOR (1-238) (3 entities in total)
• 機能のキーワード: cytokine, hormone-receptor complex, phage display molecular plasticity, receptor homodimerization, human growth hormone, hormone-growth factor complex, hormone/growth factor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Growth hormone-binding protein: Secreted: P10912
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 153612.34

構造登録者

Schiffer, C.A.,Ultsch, M.,Walsh, S.,Somers, W.,De Vos, A.M.,Kossiakoff, A.A. (登録日: 2001-11-19, 公開日: 2002-11-20, 最終更新日: 2011-07-13)

• 主引用文献: Schiffer, C.A.,Ultsch, M.,Walsh, S.,Somers, W.,De Vos, A.M.,Kossiakoff, A.A.; Structure of a Phage Display Derived Variant of Human Growth Hormone Complexed to Two Copies of the Extracellular Domain of its Receptor: Evidence for Strong Structural Coupling between Receptor Binding Sites; J.Mol.Biol., 316:277-289, 2002; PubMed: 11851338; DOI: 10.1006/jmbi.2001.5348

実験手法

X-RAY DIFFRACTION (2.6 Å)