1JPS

Crystal structure of tissue factor in complex with humanized Fab D3h44

Summary for 1JPS

• Entry DOI: 10.2210/pdb1jps/pdb
• Related: 1JPT 2HFT
• Descriptor: immunoglobulin Fab D3H44, light chain, immunoglobulin Fab D3H44, heavy chain, tissue factor, ... (4 entities in total)
• Functional Keywords: antigen-antibody recognition, humanized antibody, blood coagulation, interface water molecules, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform 1: Membrane ; Single-pass type I membrane protein . Isoform 2: Secreted : P13726
• Total number of polymer chains: 3
• Total formula weight: 72393.42

Authors

Faelber, K.,Kirchhofer, D.,Presta, L.,Kelley, R.F.,Muller, Y.A. (deposition date: 2001-08-03, release date: 2002-02-03, Last modification date: 2023-10-25)

• Primary citation: Faelber, K.,Kirchhofer, D.,Presta, L.,Kelley, R.F.,Muller, Y.A.; The 1.85 A resolution crystal structures of tissue factor in complex with humanized Fab D3h44 and of free humanized Fab D3h44: revisiting the solvation of antigen combining sites.; J.Mol.Biol., 313:83-97, 2001; PubMed: 11601848; DOI: 10.1006/jmbi.2001.5036

Experimental method

X-RAY DIFFRACTION (1.85 Å)