1JIZ

Crystal Structure Analysis of human Macrophage Elastase MMP-12

Summary for 1JIZ

Entry DOI	10.2210/pdb1jiz/pdb
Descriptor	macrophage elastase MMP-12, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	matrix metalloproteinase, mmp-12, chronic obstructive pulmonary disease, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted, extracellular space, extracellular matrix (Probable): P39900
Total number of polymer chains	2
Total formula weight	38104.12
Authors	Nar, H.,Werle, K.,Bauer, M.M.T.,Dollinger, H.,Jung, B. (deposition date: 2001-07-03, release date: 2002-07-03, Last modification date: 2024-02-07)
Primary citation	Nar, H.,Werle, K.,Bauer, M.M.,Dollinger, H.,Jung, B. Crystal structure of human macrophage elastase (MMP-12) in complex with a hydroxamic acid inhibitor. J.Mol.Biol., 312:743-751, 2001 Cited by PubMed: 11575929 DOI: 10.1006/jmbi.2001.4953 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation