1JIP

P450eryF(A245S)/ketoconazole

Summary for 1JIP

Entry DOI	10.2210/pdb1jip/pdb
Descriptor	CYTOCHROME P450 107A1, PROTOPORPHYRIN IX CONTAINING FE, CIS-1-ACETYL-4-(4-((2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL)METHOXY)PHENYL)PIPERAZINE, ... (4 entities in total)
Functional Keywords	cytochrome p450, p450eryf, p450eryf(a245s), ketoconazole, azole drug, hydrolase
Biological source	Saccharopolyspora erythraea
Cellular location	Cytoplasm (By similarity): Q00441
Total number of polymer chains	1
Total formula weight	46185.77
Authors	Cupp-Vickery, J.R.,Garcia, C.,Hofacre, A.,McGee-Estrada, K. (deposition date: 2001-07-02, release date: 2001-10-17, Last modification date: 2024-04-03)
Primary citation	Cupp-Vickery, J.R.,Garcia, C.,Hofacre, A.,McGee-Estrada, K. Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF. J.Mol.Biol., 311:101-110, 2001 Cited by PubMed: 11469860 DOI: 10.1006/jmbi.2001.4803 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation