1IM3

Crystal Structure of the human cytomegalovirus protein US2 bound to the MHC class I molecule HLA-A2/tax

Summary for 1IM3

• Entry DOI: 10.2210/pdb1im3/pdb
• Descriptor: HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, beta-2-microglobulin, Human T-cell lymphotropic virus type 1 Tax peptide, ... (5 entities in total)
• Functional Keywords: beta sheet, beta sandwhich, immunoglobulin (ig) fold, immunoglobulin (ig)-like domain, protein complex, alpha helix, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P01892; Secreted: P61769; Host endoplasmic reticulum membrane; Single- pass type I membrane protein: P09713
• Total number of polymer chains: 16
• Total formula weight: 222813.10

Authors

Gewurz, B.E.,Gaudet, R.,Tortorella, D.,Wang, E.W.,Ploegh, H.L.,Wiley, D.C. (deposition date: 2001-05-09, release date: 2001-06-06, Last modification date: 2023-08-16)

• Primary citation: Gewurz, B.E.,Gaudet, R.,Tortorella, D.,Wang, E.W.,Ploegh, H.L.,Wiley, D.C.; Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2.; Proc.Natl.Acad.Sci.USA, 98:6794-6799, 2001; PubMed: 11391001; DOI: 10.1073/pnas.121172898

Experimental method

X-RAY DIFFRACTION (2.2 Å)