1ILG

Crystal Structure of Apo Human Pregnane X Receptor Ligand Binding Domain

Summary for 1ILG

• Entry DOI: 10.2210/pdb1ilg/pdb
• Related: 1ILH
• Descriptor: ORPHAN NUCLEAR RECEPTOR PXR (2 entities in total)
• Functional Keywords: nuclear receptor, multiple binding modes, xenobiotic, promiscuous, apo, gene regulation
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : O75469
• Total number of polymer chains: 1
• Total formula weight: 36280.87

Authors

Watkins, R.E.,Redinbo, M.R. (deposition date: 2001-05-08, release date: 2001-06-27, Last modification date: 2023-08-16)

• Primary citation: Watkins, R.E.,Wisely, G.B.,Moore, L.B.,Collins, J.L.,Lambert, M.H.,Williams, S.P.,Willson, T.M.,Kliewer, S.A.,Redinbo, M.R.; The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity.; Science, 292:2329-2333, 2001; PubMed: 11408620; DOI: 10.1126/science.1060762

Experimental method

X-RAY DIFFRACTION (2.52 Å)