1IKX

K103N Mutant HIV-1 Reverse Transcriptase in Complex with the Inhibitor PNU142721

1IKX の概要

• エントリーDOI: 10.2210/pdb1ikx/pdb
• 分子名称: POL POLYPROTEIN, 6-CHLORO-2-(1-FURO[2,3-C]PYRIDIN-5-YL-ETHYLSULFANYL)-PYRIMIDIN-4-YLAMINE, ... (4 entities in total)
• 機能のキーワード: heterodimer, protein-inhibitor complex, transferase
• 由来する生物種: Human immunodeficiency virus 1; 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 114720.08

構造登録者

Lindberg, J.,Unge, T. (登録日: 2001-05-07, 公開日: 2001-06-06, 最終更新日: 2024-02-07)

• 主引用文献: Lindberg, J.,Sigurdsson, S.,Lowgren, S.,Andersson, H.O.,Sahlberg, C.,Noreen, R.,Fridborg, K.,Zhang, H.,Unge, T.; Structural basis for the inhibitory efficacy of efavirenz (DMP-266), MSC194 and PNU142721 towards the HIV-1 RT K103N mutant.; Eur.J.Biochem., 269:1670-1677, 2002; PubMed: 11895437; DOI: 10.1046/j.1432-1327.2002.02811.x

実験手法

X-RAY DIFFRACTION (2.8 Å)