1IGX

Crystal Structure of Eicosapentanoic Acid Bound in the Cyclooxygenase Channel of Prostaglandin Endoperoxide H Synthase-1.

1IGX の概要

• エントリーDOI: 10.2210/pdb1igx/pdb
• 関連するPDBエントリー: 1DIY 1FE2 1IGZ
• 分子名称: Prostaglandin Endoperoxide H Synthase-1, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• 機能のキーワード: membrane protein, fatty acid, eicosapentanoic acid, oxidoreductase, peroxidase, dioxygenase
• 由来する生物種: Ovis aries (sheep)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 69611.36

構造登録者

Malkowski, M.G.,Thuresson, E.D.,Smith, W.L.,Garavito, R.M. (登録日: 2001-04-18, 公開日: 2001-12-12, 最終更新日: 2023-08-16)

• 主引用文献: Malkowski, M.G.,Thuresson, E.D.,Lakkides, K.M.,Rieke, C.J.,Micielli, R.,Smith, W.L.,Garavito, R.M.; Structure of eicosapentaenoic and linoleic acids in the cyclooxygenase site of prostaglandin endoperoxide H synthase-1.; J.Biol.Chem., 276:37547-37555, 2001; PubMed: 11477109; DOI: 10.1074/jbc.M105982200

実験手法

X-RAY DIFFRACTION (3.1 Å)