1IEM

Crystal Structure of AmpC beta-lactamase from E. coli in Complex with a Boronic Acid Inhibitor (1, CefB4)

Summary for 1IEM

Entry DOI	10.2210/pdb1iem/pdb
Related	1C3B 1FSW 1FSY 1GA9 2BLS 3BLS
Descriptor	beta-lactamase, PHOSPHATE ION, PINACOL[[2-AMINO-ALPHA-(1-CARBOXY-1-METHYLETHOXYIMINO)-4-THIAZOLEACETYL]AMINO]METHANEBORONATE, ... (4 entities in total)
Functional Keywords	cephalosporinase, beta-lactamase, serine hydrolase, hydrolase
Biological source	Escherichia coli
Cellular location	Periplasm: P00811
Total number of polymer chains	2
Total formula weight	79931.07
Authors	Powers, R.A.,Caselli, E.,Focia, P.J.,Prati, F.,Shoichet, B.K. (deposition date: 2001-04-10, release date: 2001-08-15, Last modification date: 2023-08-09)
Primary citation	Powers, R.A.,Caselli, E.,Focia, P.J.,Prati, F.,Shoichet, B.K. Structures of ceftazidime and its transition-state analogue in complex with AmpC beta-lactamase: implications for resistance mutations and inhibitor design. Biochemistry, 40:9207-9214, 2001 Cited by PubMed: 11478888 DOI: 10.1021/bi0109358 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation