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1IA4

Candida albicans dihydrofolate reductase complex in which the dihydronicotinamide moiety of dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) is displaced by 5-{[4-(4-MORPHOLINYL)PHENYL]SULFANYL}-2,4-QUINAZOLINEDIAMIN (GW2021)

1IA4 の概要
エントリーDOI10.2210/pdb1ia4/pdb
関連するPDBエントリー1AI9 1AOE 1IA1 1IA2 1IA3
分子名称DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-(4-MORPHOLIN-4-YL-PHENYLSULFANYL)-2,4-QUINAZOLINEDIAMINE, ... (5 entities in total)
機能のキーワードoxidoreductase, antifungal target, reductase, dihydronicotinamide displaced
由来する生物種Candida albicans
タンパク質・核酸の鎖数2
化学式量合計46977.25
構造登録者
Whitlow, M.,Howard, A.J.,Kuyper, L.F. (登録日: 2001-03-22, 公開日: 2001-04-11, 最終更新日: 2023-08-09)
主引用文献Whitlow, M.,Howard, A.J.,Stewart, D.,Hardman, K.D.,Chan, J.H.,Baccanari, D.P.,Tansik, R.L.,Hong, J.S.,Kuyper, L.F.
X-ray Crystal Structures of Candida albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH is Displaced by an inhibitor
J.Med.Chem., 44:2928-2932, 2001
Cited by
PubMed: 11520201
DOI: 10.1021/jm0101444
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (1.85 Å)
構造検証レポート
Validation report summary of 1ia4
検証レポート(詳細版)ダウンロードをダウンロード

217705

件を2024-03-27に公開中

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