1IA1

Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) and 5-(PHENYLSULFANYL)-2,4-QUINAZOLINEDIAMINE (GW997)

1IA1 の概要

• エントリーDOI: 10.2210/pdb1ia1/pdb
• 関連するPDBエントリー: 1AI9 1AOE 1IA2 1IA3 1IA4
• 分子名称: DIHYDROFOLATE REDUCTASE, PHOSPHATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
• 機能のキーワード: oxidoreductase, antifungal target, reductase
• 由来する生物種: Candida albicans
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 46606.51

構造登録者

Whitlow, M.,Howard, A.J.,Kuyper, L.F. (登録日: 2001-03-22, 公開日: 2001-04-11, 最終更新日: 2023-08-09)

• 主引用文献: Whitlow, M.,Howard, A.J.,Stewart, D.,Hardman, K.D.,Chan, J.H.,Baccanari, D.P.,Tansik, R.L.,Hong, J.S.,Kuyper, L.F.; X-ray Crystal Structures of Candida albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH is Displaced by an inhibitor; J.Med.Chem., 44:2928-2932, 2001; PubMed: 11520201; DOI: 10.1021/jm0101444

実験手法

X-RAY DIFFRACTION (1.7 Å)