1I44
CRYSTALLOGRAPHIC STUDIES OF AN ACTIVATION LOOP MUTANT OF THE INSULIN RECEPTOR TYROSINE KINASE
Summary for 1I44
Entry DOI | 10.2210/pdb1i44/pdb |
Related | 1IR3 1IRK |
Descriptor | INSULIN RECEPTOR, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (4 entities in total) |
Functional Keywords | protein tyrosine kinase, phosphotransferase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P06213 |
Total number of polymer chains | 1 |
Total formula weight | 35278.31 |
Authors | Till, J.H.,Ablooglu, A.J.,Frankel, M.,Kohanski, R.A.,Hubbard, S.R. (deposition date: 2001-02-19, release date: 2001-03-07, Last modification date: 2023-08-09) |
Primary citation | Till, J.H.,Ablooglu, A.J.,Frankel, M.,Bishop, S.M.,Kohanski, R.A.,Hubbard, S.R. Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism. J.Biol.Chem., 276:10049-10055, 2001 Cited by PubMed: 11124964DOI: 10.1074/jbc.M010161200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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