1HYS

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A POLYPURINE TRACT RNA:DNA

Summary for 1HYS

• Entry DOI: 10.2210/pdb1hys/pdb
• Related: 1DLO 1RTD 2HMI
• Descriptor: 5'-R(*UP*CP*AP*GP*CP*CP*AP*CP*UP*UP*UP*UP*UP*AP*AP*AP*AP*GP*AP*AP*AP*AP*G)-3', 5'-D(*CP*TP*TP*TP*TP*CP*TP*TP*TP*TP*AP*AP*AP*AP*AP*GP*TP*GP*GP*CP*TP*G)-3', HIV-1 REVERSE TRANSCRIPTASE, ... (6 entities in total)
• Functional Keywords: polypurine tract, ppt, protein-nucleic acid complex, rnase h, rna:dna, unpaired base, rnase h primer grip, transferase-dna-rna complex, transferase-dna-rna hybrid complex, transferase/dna-rna hybrid
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366
• Total number of polymer chains: 6
• Total formula weight: 173779.96

Authors

Sarafianos, S.G.,Das, K.,Tantillo, C.,Clark Jr., A.D.,Ding, J.,Whitcomb, J.,Boyer, P.L.,Hughes, S.H.,Arnold, E. (deposition date: 2001-01-22, release date: 2001-03-26, Last modification date: 2023-08-09)

• Primary citation: Sarafianos, S.G.,Das, K.,Tantillo, C.,Clark Jr., A.D.,Ding, J.,Whitcomb, J.M.,Boyer, P.L.,Hughes, S.H.,Arnold, E.; Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNA.; EMBO J., 20:1449-1461, 2001; PubMed: 11250910; DOI: 10.1093/emboj/20.6.1449

Experimental method

X-RAY DIFFRACTION (3 Å)