1HXB

HIV-1 proteinase complexed with RO 31-8959

1HXB の概要

• エントリーDOI: 10.2210/pdb1hxb/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000454
• 分子名称: HIV-1 PROTEASE, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide (3 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, aspartyl protease, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (CLONE 12)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22250.30

構造登録者

Graves, B.J.,Hatada, M.H.,Crowther, R.L. (登録日: 1996-09-13, 公開日: 1997-03-12, 最終更新日: 2024-02-07)

• 主引用文献: Krohn, A.,Redshaw, S.,Ritchie, J.C.,Graves, B.J.,Hatada, M.H.; Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere.; J.Med.Chem., 34:3340-3342, 1991; PubMed: 1956054; DOI: 10.1021/jm00115a028

実験手法

X-RAY DIFFRACTION (2.3 Å)