1HWH

1:1 COMPLEX OF HUMAN GROWTH HORMONE MUTANT G120R WITH ITS SOLUBLE BINDING PROTEIN

1HWH の概要

• エントリーDOI: 10.2210/pdb1hwh/pdb
• 分子名称: GROWTH HORMONE, GROWTH HORMONE BINDING PROTEIN (2 entities in total)
• 機能のキーワード: cytokine, hormone, receptor, hematopoietic, complex (hormone-receptor), complex (hormone-receptor) complex, complex (hormone/receptor)
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P01241; Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Growth hormone-binding protein: Secreted: P10912
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49533.78

構造登録者

Sundstrom, S.M.,Lundqvist, T. (登録日: 1996-11-13, 公開日: 1997-11-19, 最終更新日: 2021-11-03)

• 主引用文献: Sundstrom, M.,Lundqvist, T.,Rodin, J.,Giebel, L.B.,Milligan, D.,Norstedt, G.; Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 A resolution.; J.Biol.Chem., 271:32197-32203, 1996; PubMed: 8943276; DOI: 10.1074/jbc.271.50.32197

実験手法

X-RAY DIFFRACTION (2.9 Å)