1HLF

BINDING OF GLUCOPYRANOSYLIDENE-SPIRO-THIOHYDANTOIN TO GLYCOGEN PHOSPHORYLASE B: KINETIC AND CRYSTALLOGRAPHIC STUD

Summary for 1HLF

• Entry DOI: 10.2210/pdb1hlf/pdb
• Related: 1GGN
• Descriptor: GLYCOGEN PHOSPHORYLASE, PYRIDOXAL-5'-PHOSPHATE, (5S,7R,8S,9S,10R)-8,9,10-trihydroxy-7-(hydroxymethyl)-2-thioxo-6-oxa-1,3-diazaspiro[4.5]decan-4-one, ... (4 entities in total)
• Functional Keywords: transferase, glycogen phosphorylase, inhibitor complex, catalytic site, design
• Biological source: Oryctolagus cuniculus (rabbit)
• Total number of polymer chains: 1
• Total formula weight: 97802.60

Authors

Oikonomakos, N.G.,Skamnaki, V.T.,Docsa, T.,Toth, B.,Gergely, P.,Osz, E.,Szilagyi, L.,Somsak, L. (deposition date: 2000-12-01, release date: 2000-12-13, Last modification date: 2023-08-09)

• Primary citation: Oikonomakos, N.G.,Skamnaki, V.T.,Osz, E.,Szilagyi, L.,Somsak, L.,Docsa, T.,Toth, B.,Gergely, P.; Kinetic and crystallographic studies of glucopyranosylidene spirothiohydantoin binding to glycogen phosphorylase B; BIOORG.MED.CHEM., 10:261-268, 2002; PubMed: 11741774; DOI: 10.1016/S0968-0896(01)00277-2

Experimental method

X-RAY DIFFRACTION (2.26 Å)