1H3Y

Crystal structure of a human IgG1 Fc-fragment,high salt condition

1H3Y の概要

• エントリーDOI: 10.2210/pdb1h3y/pdb
• 関連するPDBエントリー: 1AJ7 1D5B 1D5I 1D6V 1DN2 1E4K 1FC1 1FC2 1FCC 1H3T 1H3U 1H3V 1H3W 1H3X 1HZH 1I7Z 1IIS 1IIX 2RCS
• 分子名称: IG GAMMA-1 CHAIN C REGION, alpha-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• 機能のキーワード: immune system, fc-fragment, glycosylation, fcgr, antibody, effector functions
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 53504.06

構造登録者

Krapp, S.,Mimura, Y.,Jefferis, R.,Huber, R.,Sondermann, P. (登録日: 2002-09-19, 公開日: 2003-01-23, 最終更新日: 2023-12-13)

• 主引用文献: Krapp, S.,Mimura, Y.,Jefferis, R.,Huber, R.,Sondermann, P.; Structural Analysis of Human Igg-Fc Glycoforms Reveals a Correlation between Glycosylation and Structural Integrity.; J.Mol.Biol., 325:979-, 2003; PubMed: 12527303; DOI: 10.1016/S0022-2836(02)01250-0

実験手法

X-RAY DIFFRACTION (4.1 Å)