1GXF

CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN COMPLEX WITH THE INHIBITOR QUINACRINE MUSTARD

Summary for 1GXF

Entry DOI	10.2210/pdb1gxf/pdb
Related	1AOG 1NDA
Descriptor	TRYPANOTHIONE REDUCTASE (OXIDIZED FORM), FLAVIN-ADENINE DINUCLEOTIDE, MALEIC ACID, ... (5 entities in total)
Functional Keywords	oxidoreductase, trypanothione reductase, fad dependent, disulphide oxidoreductase, quinacrine mustard, inhibitor, redox-active center, flavoprotein, fad, nadp
Biological source	TRYPANOSOMA CRUZI
Cellular location	Cytoplasm: P28593
Total number of polymer chains	2
Total formula weight	111413.90
Authors	Bond, C.S.,Peterson, M.R.,Vickers, T.J.,Fairlamb, A.H.,Hunter, W.N. (deposition date: 2002-04-04, release date: 2004-05-06, Last modification date: 2023-12-13)
Primary citation	Saravanamuthu, A.,Vickers, T.J.,Bond, C.S.,Peterson, M.R.,Hunter, W.N.,Fairlamb, A.H. Two Interacting Binding Sites for Quinacrine Derivatives in the Active Site of Trypanothione Reductase: A Template for Drug Design J.Biol.Chem., 279:29493-, 2004 Cited by PubMed: 15102853 DOI: 10.1074/JBC.M403187200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation