1GXC

FHA domain from human Chk2 kinase in complex with a synthetic phosphopeptide

Summary for 1GXC

Entry DOI	10.2210/pdb1gxc/pdb
Descriptor	SERINE/THREONINE-PROTEIN KINASE CHK2, SYNTHETIC PHOSPHOPEPTIDE (3 entities in total)
Functional Keywords	phosphoprotein-binding domain, checkpoint kinase, transferase, serine/threonine-protein kinase
Biological source	HOMO SAPIENS (HUMAN) More
Cellular location	Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017
Total number of polymer chains	8
Total formula weight	75587.18
Authors	Li, J.,Williams, B.L.,Haire, L.F.,Goldberg, M.,Wilker, E.,Durocher, D.,Yaffe, M.B.,Jackson, S.P.,Smerdon, S.J. (deposition date: 2002-04-02, release date: 2002-06-13, Last modification date: 2016-12-21)
Primary citation	Li, J.,Williams, B.L.,Haire, L.F.,Goldberg, M.,Wilker, E.,Durocher, D.,Yaffe, M.B.,Jackson, S.P.,Smerdon, S.J. Structural and Functional Versatility of the Fha Domain in DNA-Damage Signaling by the Tumor Suppressor Kinase Chk2 Mol.Cell, 9:1045-, 2002 Cited by PubMed: 12049740 DOI: 10.1016/S1097-2765(02)00527-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation