1GX5

Hepatitis C Virus RNA Polymerase in Complex with GTP and Manganese

1GX5 の概要

• エントリーDOI: 10.2210/pdb1gx5/pdb
• 関連するPDBエントリー: 1C2P 1CSJ 1CU1 1NS3 1QUV 8OHM
• 分子名称: RNA-DIRECTED RNA POLYMERASE, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... (4 entities in total)
• 機能のキーワード: transferase, polyprotein, glycoprotein, rna-directed rna polymerase, core protein, coat protein, envelope protein, helicase, atp binding, transmembrane, nonstructural protein
• 由来する生物種: HEPATITIS C VIRUS (ISOLATE BK) (HCV)
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26663
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61415.43

構造登録者

Bressanelli, S.,Rey, F.A. (登録日: 2002-03-27, 公開日: 2002-04-09, 最終更新日: 2023-12-13)

• 主引用文献: Bressanelli, S.,Tomei, L.,Rey, F.A.,De Francesco, R.; A Structural Analysis of the Hepatitis C Virus RNA Polymerase in Complex with Ribonucleotides; J.Virol., 76:3482-, 2002; PubMed: 11884572; DOI: 10.1128/JVI.76.7.3482-3492.2002

実験手法

X-RAY DIFFRACTION (1.7 Å)