1GS4

Structural basis for the glucocorticoid response in a mutant human androgen receptor (ARccr) derived from an androgen-independent prostate cancer

Summary for 1GS4

• Entry DOI: 10.2210/pdb1gs4/pdb
• Related: 1E3G
• Descriptor: ANDROGEN RECEPTOR, 9ALPHA-FLUOROCORTISOL, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: androgen receptor, human androgen receptor, ligand-binding domain, cortisol/ cortisone response, prostate cancer
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Nucleus : P10275
• Total number of polymer chains: 1
• Total formula weight: 29415.36

Authors

Matias, P.M.,Carrondo, M.A.,Coelho, R.,Thomaz, M.,Zhao, X.-Y.,Wegg, A.,Crusius, K.,Egner, U.,Donner, P. (deposition date: 2001-12-27, release date: 2003-01-16, Last modification date: 2023-12-13)

• Primary citation: Matias, P.M.,Carrondo, M.A.,Coelho, R.,Thomaz, M.,Zhao, X.-Y.,Wegg, A.,Crusius, K.,Egner, U.,Donner, P.; Structural Basis for the Glucocorticoid Response in a Mutant Human Androgen Receptor (Ar(Ccr)) Derived from an Androgen-Independent Prostate Cancer; J.Med.Chem., 45:1439-1446, 2002; PubMed: 11906285; DOI: 10.1021/JM011072J

Experimental method

X-RAY DIFFRACTION (1.95 Å)