1GRH

INHIBITION OF HUMAN GLUTATHIONE REDUCTASE BY THE NITROSOUREA DRUGS 1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA AND 1-(2-CHLOROETHYL)-3-(2-HYDROXYETHYL)-1-NITROSOUREA

Summary for 1GRH

Entry DOI	10.2210/pdb1grh/pdb
Related	1GRG
Descriptor	GLUTATHIONE REDUCTASE, PHOSPHATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
Functional Keywords	oxidoreductase, flavoenzyme
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm: P00390
Total number of polymer chains	1
Total formula weight	52562.83
Authors	Karplus, P.A.,Schulz, G.E. (deposition date: 1992-12-15, release date: 1994-01-31, Last modification date: 2011-07-27)
Primary citation	Karplus, P.A.,Krauth-Siegel, R.L.,Schirmer, R.H.,Schulz, G.E. Inhibition of human glutathione reductase by the nitrosourea drugs 1,3-bis(2-chloroethyl)-1-nitrosourea and 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea. A crystallographic analysis. Eur.J.Biochem., 171:193-198, 1988 Cited by PubMed: 3338461 DOI: 10.1111/j.1432-1033.1988.tb13775.x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation