1GO9

Monitoring the structural Consequences of Phe12-->D-Phe12 and Leu15-->Aib15 substitution in h/r Corticotropin Releasing Hormone: Implications for Design of CRH antagonists.

Summary for 1GO9

Entry DOI	10.2210/pdb1go9/pdb
Descriptor	CORTICOTROPIN RELEASING HORMONE (1 entity in total)
Functional Keywords	hormone, corticotropin releasing hormone, synthetic analogues, solid phase synthesis, solutions structure
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Secreted : P06850
Total number of polymer chains	1
Total formula weight	4734.44
Authors	Spyroulias, G.A.,Papazacharias, S.,Pairas, G.,Cordopatis, P. (deposition date: 2001-10-20, release date: 2001-10-31, Last modification date: 2016-12-21)
Primary citation	Spyroulias, G.A.,Papazacharias, S.,Pairas, G.,Cordopatis, P. Monitoring the Structural Consequences of Phe12-->D-Phe and Leu15-->Aib Substitution in Human/Rat Corticotropin Releasing Hormone. Implications for Design of Crh Antagonists. Eur.J.Biochem., 269:6009-, 2002 Cited by PubMed: 12473096 DOI: 10.1046/J.1432-1033.2002.03278.X PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation