1GGN
Structures of glycogen phosphorylase-inhibitor complexes and the implications for structure-based drug design
Summary for 1GGN
| Entry DOI | 10.2210/pdb1ggn/pdb |
| Related | 1A8I |
| Descriptor | PROTEIN (GLYCOGEN PHOSPHORYLASE), BETA-D-GLUCOPYRANOSE SPIROHYDANTOIN, PYRIDOXAL-5'-PHOSPHATE, ... (4 entities in total) |
| Functional Keywords | transferase, glycogen phosphorylase, inhibitor complex, catalytic site, design |
| Biological source | Oryctolagus cuniculus (rabbit) |
| Total number of polymer chains | 1 |
| Total formula weight | 97786.54 |
| Authors | Watson, K.A.,Tsitsanou, K.E.,Gregoriou, M.,Zographos, S.E.,Skamnaki, V.T.,Oikonomakos, N.G.,Fleet, G.W.,Johnson, L.N. (deposition date: 2000-08-29, release date: 2000-09-13, Last modification date: 2023-08-09) |
| Primary citation | Oikonomakos, N.G.,Skamnaki, V.T.,Osz, E.,Szilagyi, L.,Somsak, L.,Docsa, T.,Toth, B.,Gergely, P. Kinetic and crystallographic studies of glucopyranosylidene spirothiohydantoin binding to glycogen phosphorylase B. Bioorg.Med.Chem., 10:261-268, 2002 Cited by PubMed: 11741774DOI: 10.1016/S0968-0896(01)00277-2 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.36 Å) |
Structure validation
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