1GFY

RESIDUE 259 IS A KEY DETERMINANT OF SUBSTRATE SPECIFICITY OF PROTEIN-TYROSINE PHOSPHATASE 1B AND ALPHA

Summary for 1GFY

Entry DOI	10.2210/pdb1gfy/pdb
Related	1C83 1C84 1C85 1C86 1C87 1C88 1ECV
Descriptor	PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B), 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]THIOPYRAN-3-CARBOXYLIC ACID (3 entities in total)
Functional Keywords	hydrolase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
Total number of polymer chains	1
Total formula weight	34991.85
Authors	Iversen, L.F. (deposition date: 2000-06-26, release date: 2000-07-04, Last modification date: 2023-12-27)
Primary citation	Peters, G.H.,Iversen, L.F.,Branner, S.,Andersen, H.S.,Mortensen, S.B.,Olsen, O.H.,Moller, K.B.,Moller, N.P. Residue 259 is a key determinant of substrate specificity of protein-tyrosine phosphatases 1B and alpha. J.Biol.Chem., 275:18201-18209, 2000 Cited by PubMed: 10748206 DOI: 10.1074/jbc.M910273199 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.13 Å)

Structure validation