1GA0

STRUCTURE OF THE E. CLOACAE GC1 BETA-LACTAMASE WITH A CEPHALOSPORIN SULFONE INHIBITOR

Summary for 1GA0

Entry DOI	10.2210/pdb1ga0/pdb
Related	1BLS 1GCE 2BLT
Descriptor	BETA-LACTAMASE, SODIUM ION, 3-(4-CARBAMOYL-1-CARBOXY-2-METHYLSULFONYL-BUTA-1,3-DIENYLAMINO)-INDOLIZINE-2-CARBOXYLIC ACID, ... (5 entities in total)
Functional Keywords	mixed alpha/beta, cephalosporinase, inhibition, conformational change, class c beta-lactamase, hydrolase
Biological source	Enterobacter cloacae
Total number of polymer chains	1
Total formula weight	40101.63
Authors	Crichlow, G.V.,Nukaga, M.,Buynak, J.D.,Knox, J.R. (deposition date: 2000-11-28, release date: 2001-06-06, Last modification date: 2023-08-09)
Primary citation	Crichlow, G.V.,Nukaga, M.,Doppalapudi, V.R.,Buynak, J.D.,Knox, J.R. Inhibition of class C beta-lactamases: structure of a reaction intermediate with a cephem sulfone. Biochemistry, 40:6233-6239, 2001 Cited by PubMed: 11371184 DOI: 10.1021/bi010131s PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation