1FVR

TIE2 KINASE DOMAIN

Summary for 1FVR

• Entry DOI: 10.2210/pdb1fvr/pdb
• Descriptor: TYROSINE-PROTEIN KINASE TIE-2 (2 entities in total)
• Functional Keywords: tyrosine kinase, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane ; Single-pass type I membrane protein: Q02763
• Total number of polymer chains: 2
• Total formula weight: 75057.62

Authors

Shewchuk, L.M.,Hassell, A.M.,Ellis, B.,Holmes, W.D.,Davis, R.,Horne, E.L.,Kadwell, S.H.,McKee, D.D.,Moore, J.T. (deposition date: 2000-09-20, release date: 2001-09-20, Last modification date: 2024-02-07)

• Primary citation: Shewchuk, L.M.,Hassell, A.M.,Ellis, B.,Holmes, W.D.,Davis, R.,Horne, E.L.,Kadwell, S.H.,McKee, D.D.,Moore, J.T.; Structure of the Tie2 RTK domain: self-inhibition by the nucleotide binding loop, activation loop, and C-terminal tail.; Structure Fold.Des., 8:1105-1113, 2000; PubMed: 11080633; DOI: 10.1016/S0969-2126(00)00516-5

Experimental method

X-RAY DIFFRACTION (2.2 Å)