1FTQ

STRUCTURES OF GLYCOGEN PHOSPHORYLASE-INHIBITOR COMPLEXES AND THE IMPLICATIONS FOR STRUCTURE-BASED DRUG DESIGN

Summary for 1FTQ

Entry DOI	10.2210/pdb1ftq/pdb
Related	1B4D 1FS4 1FTW 1FTY 1FU4 1FU7 1FU8 1GGN
Descriptor	GLYCOGEN PHOSPHORYLASE, (5S,7R,8S,9S,10R)-3-amino-8,9,10-trihydroxy-7-(hydroxymethyl)-6-oxa-1,3-diazaspiro[4.5]decane-2,4-dione, PYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
Functional Keywords	transferase, glycogen phosphorylase, inhibitor complex, catalytic site, design
Biological source	Oryctolagus cuniculus (rabbit)
Total number of polymer chains	1
Total formula weight	98149.76
Authors	Watson, K.A.,Tsitsanou, K.E.,Gregoriou, M.,Zographos, S.E.,Skamnaki, V.T.,Oikonomakos, N.G.,Fleet, G.W.,Johnson, L.N. (deposition date: 2000-09-13, release date: 2000-10-04, Last modification date: 2023-08-09)
Primary citation	Watson, K.A.,Chrysina, E.D.,Tsitsanou, K.E.,Zographos, S.E.,Archontis, G.,Fleet, G.W.,Oikonomakos, N.G. Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase. Proteins, 61:966-983, 2005 Cited by PubMed: 16222658 DOI: 10.1002/prot.20653 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation