1FR6

REFINED CRYSTAL STRUCTURE OF BETA-LACTAMASE FROM CITROBACTER FREUNDII INDICATES A MECHANISM FOR BETA-LACTAM HYDROLYSIS

Summary for 1FR6

• Entry DOI: 10.2210/pdb1fr6/pdb
• Related: 1FR1
• Descriptor: BETA-LACTAMASE, 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid (3 entities in total)
• Functional Keywords: hydrolase, antibiotic resistance, class c beta-lactamase, monobactum
• Biological source: Citrobacter freundii
• Total number of polymer chains: 2
• Total formula weight: 80385.40

Authors

Oefner, C.,D'Arcy, A.,Daly, J.J.,Winkler, F.K. (deposition date: 2000-09-07, release date: 2001-01-17, Last modification date: 2017-10-04)

• Primary citation: Oefner, C.,D'Arcy, A.,Daly, J.J.,Gubernator, K.,Charnas, R.L.,Heinze, I.,Hubschwerlen, C.,Winkler, F.K.; Refined crystal structure of beta-lactamase from Citrobacter freundii indicates a mechanism for beta-lactam hydrolysis.; Nature, 343:284-288, 1990; PubMed: 2300174; DOI: 10.1038/343284a0

Experimental method

X-RAY DIFFRACTION (2.5 Å)