1FKN

Structure of Beta-Secretase Complexed with Inhibitor

Summary for 1FKN

Entry DOI	10.2210/pdb1fkn/pdb
Related PRD ID	PRD_000290
Descriptor	MEMAPSIN 2, inhibitor (3 entities in total)
Functional Keywords	alzheimer's disease, beta-secretase, memapsin 2, base, aspartic protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P56817
Total number of polymer chains	4
Total formula weight	89040.37
Authors	Hong, L.,Koelsch, G.,Lin, X.,Wu, S.,Terzyan, S.,Ghosh, A.,Zhang, X.C.,Tang, J. (deposition date: 2000-08-09, release date: 2000-10-09, Last modification date: 2023-11-15)
Primary citation	Hong, L.,Koelsch, G.,Lin, X.,Wu, S.,Terzyan, S.,Ghosh, A.K.,Zhang, X.C.,Tang, J. Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Science, 290:150-153, 2000 Cited by PubMed: 11021803 DOI: 10.1126/science.290.5489.150 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation