1F93

CRYSTAL STRUCTURE OF A COMPLEX BETWEEN THE DIMERIZATION DOMAIN OF HNF-1 ALPHA AND THE COACTIVATOR DCOH

Summary for 1F93

Entry DOI	10.2210/pdb1f93/pdb
Descriptor	DIMERIZATION COFACTOR OF HEPATOCYTE NUCLEAR FACTOR 1-ALPHA, HEPATOCYTE NUCLEAR FACTOR 1-ALPHA (3 entities in total)
Functional Keywords	four-helix bundle, transcriptional activator-coactivator complex, dimerization domain, transcription
Biological source	Rattus norvegicus (Norway rat) More
Cellular location	Cytoplasm: P61459 Nucleus: P22361
Total number of polymer chains	8
Total formula weight	62180.96
Authors	Rose, R.B.,Bayle, J.H.,Endrizzi, J.A.,Cronk, J.D.,Crabtree, G.R.,Alber, T. (deposition date: 2000-07-06, release date: 2000-09-20, Last modification date: 2011-07-13)
Primary citation	Rose, R.B.,Bayle, J.H.,Endrizzi, J.A.,Cronk, J.D.,Crabtree, G.R.,Alber, T. Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha. Nat.Struct.Biol., 7:744-748, 2000 Cited by PubMed: 10966642 DOI: 10.1038/78966 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation