1F6T

STRUCTURE OF THE NUCLEOSIDE DIPHOSPHATE KINASE/ALPHA-BORANO(RP)-TDP.MG COMPLEX

Summary for 1F6T

Entry DOI	10.2210/pdb1f6t/pdb
Related	1F3F 1LWX
Descriptor	PROTEIN (NUCLEOSIDE DIPHOSPHATE KINASE), MAGNESIUM ION, 2-DEOXY-THYMIDINE-5-ALPHA BORANO DIPHOSPHATE (ISOMER RP), ... (4 entities in total)
Functional Keywords	nucleoside diphosphate kinase, anti-hiv nucleoside analogue, phosphorylation, boranophosphate, transferase
Biological source	Dictyostelium discoideum
Cellular location	Cytoplasm: P22887
Total number of polymer chains	3
Total formula weight	51722.00
Authors	Guerreiro, C.,Boretto, J.,Janin, J.,Veron, M.,Canard, B.,Schneider, B.,Sarfati, S.,Deville-Bonne, D. (deposition date: 2000-06-23, release date: 2000-09-13, Last modification date: 2024-02-07)
Primary citation	Meyer, P.,Schneider, B.,Sarfati, S.,Deville-Bonne, D.,Guerreiro, C.,Boretto, J.,Janin, J.,Veron, M.,Canard, B. Structural basis for activation of alpha-boranophosphate nucleotide analogues targeting drug-resistant reverse transcriptase. EMBO J., 19:3520-3529, 2000 Cited by PubMed: 10899107 DOI: 10.1093/emboj/19.14.3520 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.92 Å)

Structure validation