1ERQ

X-RAY CRYSTAL STRUCTURE OF TEM-1 BETA LACTAMASE IN COMPLEX WITH A DESIGNED BORONIC ACID INHIBITOR (1R)-1-ACETAMIDO-2-(3-CARBOXY-2-HYDROXYPHENYL)ETHYL BORONIC ACID

Summary for 1ERQ

• Entry DOI: 10.2210/pdb1erq/pdb
• Related: 1ERM 1ERO
• Descriptor: TEM-1 BETA-LACTAMASE, 1(R)-1-ACETAMIDO-2-(3-CARBOXY-2-HYDROXYPHENYL)ETHYL BORONIC ACID (3 entities in total)
• Functional Keywords: beta-lactamase, structure-based design, boronate inhibitor, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 29209.04

Authors

Ness, S.,Martin, R.,Kindler, A.M.,Paetzel, M.,Gold, M.,Jones, J.B.,Strynadka, N.C.J. (deposition date: 2000-04-06, release date: 2000-05-10, Last modification date: 2011-07-13)

• Primary citation: Ness, S.,Martin, R.,Kindler, A.M.,Paetzel, M.,Gold, M.,Jensen, S.E.,Jones, J.B.,Strynadka, N.C.; Structure-based design guides the improved efficacy of deacylation transition state analogue inhibitors of TEM-1 beta-Lactamase(,).; Biochemistry, 39:5312-5321, 2000; PubMed: 10820001; DOI: 10.1021/bi992505b

Experimental method

X-RAY DIFFRACTION (1.9 Å)