1EQG

THE 2.6 ANGSTROM MODEL OF OVINE COX-1 COMPLEXED WITH IBUPROFEN

Summary for 1EQG

• Entry DOI: 10.2210/pdb1eqg/pdb
• Related: 1EQH
• Descriptor: PROSTAGLANDIN H2 SYNTHASE-1, 2-acetamido-2-deoxy-beta-D-glucopyranose, octyl beta-D-glucopyranoside, ... (6 entities in total)
• Functional Keywords: egf domain, nsaid binding, ibuprofen, membrane-binding domain, cyclooxygenase, peroxidase, oxidoreductase, dioxygenase
• Biological source: Ovis aries (sheep)
• Total number of polymer chains: 2
• Total formula weight: 137925.36

Authors

Loll, P.J.,Selinsky, B.S.,Gupta, K.,Sharkey, C.T. (deposition date: 2000-04-04, release date: 2001-04-11, Last modification date: 2024-03-13)

• Primary citation: Selinsky, B.S.,Gupta, K.,Sharkey, C.T.,Loll, P.J.; Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations.; Biochemistry, 40:5172-5180, 2001; PubMed: 11318639; DOI: 10.1021/bi010045s

Experimental method

X-RAY DIFFRACTION (2.61 Å)