1EP4

Crystal structure of HIV-1 reverse transcriptase in complex with S-1153

Summary for 1EP4

• Entry DOI: 10.2210/pdb1ep4/pdb
• Related: 1C0T 1C0U 1C1B 1C1C 1DTQ 1DTT 1KLM 1REV 1RT1 1RT2 1RT3 1RT4 1RT5 1RT6 1RT7 1RTH 1RTI 1RTJ 1VRT 1VRU
• Descriptor: HIV-1 REVERSE TRANSCRIPTASE, 5-(3,5-DICHLOROPHENYL)THIO-4-ISOPROPYL-1-(PYRIDIN-4-YL-METHYL)-1H-IMIDAZOL-2-YL-METHYL CARBAMATE, ... (4 entities in total)
• Functional Keywords: hiv-1 reverse transcriptase, aids, non-nucleoside inhibitor, s-1153, drug design, transferase
• Biological source: Human immunodeficiency virus 1; More
• Cellular location: Matrix protein p17: Virion . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
• Total number of polymer chains: 2
• Total formula weight: 116445.37

Authors

Ren, J.,Nichols, C.,Bird, L.E.,Fujiwara, T.,Suginoto, H.,Stuart, D.I.,Stammers, D.K. (deposition date: 2000-03-27, release date: 2000-09-27, Last modification date: 2014-11-12)

• Primary citation: Ren, J.,Nichols, C.,Bird, L.E.,Fujiwara, T.,Sugimoto, H.,Stuart, D.I.,Stammers, D.K.; Binding of the second generation non-nucleoside inhibitor S-1153 to HIV-1 reverse transcriptase involves extensive main chain hydrogen bonding.; J.Biol.Chem., 275:14316-14320, 2000; PubMed: 10799511; DOI: 10.1074/jbc.275.19.14316

Experimental method

X-RAY DIFFRACTION (2.5 Å)