1EK2
CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CDU INHIBITOR
Summary for 1EK2
| Entry DOI | 10.2210/pdb1ek2/pdb |
| Related | 1CQZ 1CR6 1EK1 |
| Descriptor | EPOXIDE HYDROLASE, N-CYCLOHEXYL-N'-DECYLUREA (3 entities in total) |
| Functional Keywords | homodimer, alpha/beta hydrolase fold, disubstituted urea inhibitor, hydrolase |
| Biological source | Mus musculus (house mouse) |
| Cellular location | Cytoplasm: P34914 |
| Total number of polymer chains | 2 |
| Total formula weight | 125729.01 |
| Authors | Argiriadi, M.A.,Morisseau, C.,Goodrow, M.H.,Dowdy, D.L.,Hammock, B.D.,Christianson, D.W. (deposition date: 2000-03-06, release date: 2000-05-31, Last modification date: 2024-02-07) |
| Primary citation | Argiriadi, M.A.,Morisseau, C.,Goodrow, M.H.,Dowdy, D.L.,Hammock, B.D.,Christianson, D.W. Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation. J.Biol.Chem., 275:15265-15270, 2000 Cited by PubMed: 10747889DOI: 10.1074/jbc.M000278200 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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