1EA1

Cytochrome P450 14 alpha-sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with fluconazole

Summary for 1EA1

• Entry DOI: 10.2210/pdb1ea1/pdb
• Related: 1E9X
• Descriptor: CYTOCHROME P450 51-LIKE RV0764C, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, ... (4 entities in total)
• Functional Keywords: oxidoreductase, cytochrome p450, 14 alpha-sterol demethylase, azole inhibitors
• Biological source: MYCOBACTERIUM TUBERCULOSIS
• Total number of polymer chains: 1
• Total formula weight: 52422.09

Authors

Podust, L.M.,Poulos, T.L.,Waterman, M.R. (deposition date: 2000-11-02, release date: 2000-11-06, Last modification date: 2023-12-13)

• Primary citation: Podust, L.M.,Poulos, T.L.,Waterman, M.R.; Crystal Structure of Cytochrome P450 14Alpha -Sterol Demethylase (Cyp51) from Mycobacterium Tuberculosis in Complex with Azole Inhibitors; Proc.Natl.Acad.Sci.USA, 98:3068-, 2001; PubMed: 11248033; DOI: 10.1073/PNAS.061562898

Experimental method

X-RAY DIFFRACTION (2.21 Å)