1E8W

Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine

Summary for 1E8W

Entry DOI	10.2210/pdb1e8w/pdb
Related	1E7U 1E7V 1E8X 1QMM
Descriptor	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT, 3,5,7,3',4'-PENTAHYDROXYFLAVONE (2 entities in total)
Functional Keywords	phosphoinositide 3-kinase gamma, secondary messenger generation, pi3k, pi 3k, quercetin
Biological source	SUS SCROFA (WILD BOAR)
Total number of polymer chains	1
Total formula weight	110254.79
Authors	Walker, E.H.,Pacold, M.E.,Perisic, O.,Stephens, L.,Hawkins, P.T.,Wymann, M.P.,Williams, R.L. (deposition date: 2000-10-03, release date: 2000-11-17, Last modification date: 2023-12-13)
Primary citation	Walker, E.H.,Pacold, M.E.,Perisic, O.,Stephens, L.,Hawkins, P.T.,Whymann, M.P.,Williams, R.L. Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine Mol.Cell, 6:909-, 2000 Cited by PubMed: 11090628 DOI: 10.1016/S1097-2765(05)00089-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation