1E7W

One active site, two modes of reduction correlate the mechanism of leishmania pteridine reductase with pterin metabolism and antifolate drug resistance in trpanosomes

1E7W の概要

• エントリーDOI: 10.2210/pdb1e7w/pdb
• 分子名称: PTERIDINE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, METHOTREXATE, ... (5 entities in total)
• 機能のキーワード: dihydrofolate reductase, pteridine reductase, shortchain dehydrogenase, methotrexate resistance, oxidoreductase
• 由来する生物種: LEISHMANIA MAJOR
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64031.62

構造登録者

Gourley, D.G.,Hunter, W.N. (登録日: 2000-09-11, 公開日: 2001-09-06, 最終更新日: 2011-07-13)

• 主引用文献: Gourley, D.G.,Schuttelkopf, A.,Leonard, G.,Luba, J.,Hardy, L.,Beverley, S.,Hunter, W.N.; Pteridine Reductase Mechanism Correlates Pterin Metabolism with Drug Resistance in Trypanosomatid Parasites.; Nat.Struct.Biol., 8:521-, 2001; PubMed: 11373620; DOI: 10.1038/88584

実験手法

X-RAY DIFFRACTION (1.75 Å)