1E3K

Human Progesteron Receptor Ligand Binding Domain in complex with the ligand metribolone (R1881)

Summary for 1E3K

Entry DOI	10.2210/pdb1e3k/pdb
Related	1A28
Descriptor	PROGESTERONE RECEPTOR, (17BETA)-17-HYDROXY-17-METHYLESTRA-4,9,11-TRIEN-3-ONE (3 entities in total)
Functional Keywords	human progesterone receptor, ligand binding domain
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	60046.43
Authors	Matias, P.M.,Donner, P.,Coelho, R.,Thomaz, M.,Peixoto, C.,Macedo, S.,Otto, N.,Joschko, S.,Scholz, P.,Wegg, A.,Basler, S.,Schafer, M.,Egner, U.,Carrondo, M.A. (deposition date: 2000-06-19, release date: 2001-06-14, Last modification date: 2023-12-13)
Primary citation	Matias, P.M.,Donner, P.,Coelho, R.,Thomaz, M.,Peixoto, C.,Macedo, S.,Otto, N.,Joschko, S.,Scholz, P.,Wegg, A.,Basler, S.,Schafer, M.,Egner, U.,Carrondo, M.A. Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations. J. Biol. Chem., 275:26164-26171, 2000 Cited by PubMed: 10840043 DOI: 10.1074/jbc.M004571200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation