1E2J

The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography

Summary for 1E2J

Entry DOI	10.2210/pdb1e2j/pdb
Related	1E2H 1E2I 1E2K 1E2L 1E2M 1E2N 1E2P 1KI2 1KI4 1KI5 1KI6 1KI7 1KI8 1KIM 1VTK 2VTK 3VTK
Descriptor	THYMIDINE KINASE, SULFATE ION, THYMIDINE, ... (4 entities in total)
Functional Keywords	transferase, adenine analog, enzyme-prodrug gene therapy, nucleoside- binding, thymidine kinase
Biological source	HERPES SIMPLEX VIRUS (TYPE 1/STRAIN 17)
Total number of polymer chains	2
Total formula weight	72206.70
Authors	Vogt, J.,Scapozza, L.,Schulz, G.E. (deposition date: 2000-05-23, release date: 2000-11-06, Last modification date: 2023-12-06)
Primary citation	Vogt, J.,Perozzo, R.,Pautsch, A.,Prota, A.,Schelling, P.,Pilger, B.,Folkers, G.,Scapozza, L.,Schulz, G.E. Nucleoside Binding Site of Herpes Simplex Type 1 Thymidine Kinase Analyzed by X-Ray Crystallography Proteins: Struct.,Funct., Genet., 41:545-, 2000 Cited by PubMed: 11056041 DOI: 10.1002/1097-0134(20001201)41:4<545::AID-PROT110>3.0.CO;2-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation